Jimmy Harper – A wholesome, innocent, high school teenager who runs into trouble after he is lured into the dangerous world of reefer.
Lecturer – a severe authority figure who warns the audience of the perils of Reefer Madness.
Mary Lane – Jimmy’s sweetheart, a naïve, virginal teenage girl.
Jack Stone – The handsome and ruthless proprietor of the Reefer Den, a 30’s gangster movie-type.
Mae – An attractive, yet slightly haggard dame in her mid-30s, the hostess of the Reefer Den.
Ralph Wiley – a denizen of the Reefer Den, formally a fraternity man, his college days ended long ago due to his reefer habit.
Sally – a sexy and seductive resident of the Reefer Den, she possesses the libidinous soul of Mae West combined with the rat-a-tat moxie of vintage Barbara Stanwyck.
Placard Girl – throughout the play she reinforces the warnings of the Lecturer by holding large signs that clearly state the moral of what we’ve just seen.
Other characters –
- Mr. Poppy
- Irish Priest
- Old Man
- Radio Announcer
- George Washington
- Sally’s Baby
- Uncle Sam
- Lady Liberty
- Five-and-Dime Kid
- Police Officer
Ensemble – Mixed gender group to represent Reefer Zombies, Kids at the Five-and-Dime, Jungle Orgy dancers, Angels, and patriotic background chorus in the Star-Spangled finale.